demonstrated that butyrate treatment significantly inhibited proliferation and induced apoptosis in HCT116 cells with an increased BAX/BCL-2 ratio in CRC cells, and suggested that butyrate functioned via the deactivation of mTOR/S6K1 signaling mediated partly by SIRT1 downregulation (114); Yu et al. Here, BCL2 is linked to colorectal carcinoma.