In the Nlrp1b KI (hetero) mice which underwent anti-IL-1β antibody treatment before UVB irradiation, the skin inflammation and hyperkeratosis caused by the irradiation were inhibited compared with those in the Nlrp1b KI (hetero) mice with control IgG antibody treatment by intraperitoneal (i.p.)administration (Figures 5A–C) and subcutaneous (s.c.)administration (Supplemental Figure S4). The gene discussed is IL1B; the disease is Hyperkeratosis.