In particular, IgG1+ B-cells expressing the chemokine receptor CXCR3 and the transcription factor T-bet are recruited and enriched in the CNS of some MS patients, likely reflecting high levels of CXCR3 ligand CXCL10 in the CSF of these patients (58, 59). This evidence concerns the gene CXCR3 and myeloid sarcoma.