IGHE and systemic lupus erythematosus: Notably, a key study of SLE patients demonstrates that double-stranded DNA (dsDNA)-reactive IgE can trigger IFNα production via activating plasmacytoid dendritic cells (pDCs) upon binding to FcεRI on these cells, and that the serum concentrations of these dsDNA-reactive IgE correlate with disease severity (108).