Other differences in choroidal macular complement expression from early AMD eyes included a 3-fold decrease of CFD and 1.5-1.6-fold decrease of CLU in Schwann cells and fibroblasts as well as a 1.4-fold FCN1 and 1.3-fold CFD increase in macrophages compared to their cellular counterparts from peripheral AMD choroid. This evidence concerns the gene CLU and age-related macular degeneration.