METTL3 and nonpapillary renal cell carcinoma: Moreover, the expression of WTAP, YTHDC1, YTHDC2, HNRNPC, and HNRNPA2B1 was significantly different between the ICB-resistant-related GPX3+ epithelial cells and ICB-response-related VCAM1+ epithelial cells (Figure 1D), indicating that the differential expression level of m6A regulators in ccRCC tissue and cell clusters may be related to the efficacy of immunotherapy.