Moreover, the expression of WTAP, YTHDC1, YTHDC2, HNRNPC, and HNRNPA2B1 was significantly different between the ICB-resistant-related GPX3+ epithelial cells and ICB-response-related VCAM1+ epithelial cells (Figure 1D), indicating that the differential expression level of m6A regulators in ccRCC tissue and cell clusters may be related to the efficacy of immunotherapy. The gene discussed is GPX3; the disease is nonpapillary renal cell carcinoma.