To investigate the effects of MRPRS on the immune infiltration characteristic of ccRCC, we evaluated the expression of immunomodulators and the infiltration levels between high- and low-MRPRS groups in ccRCC, as shown in Figure 3B; 5 immunomodulators (chemokine, receptor, immunostimulator, inhibitory immune checkpoint, and MHC) and the infiltration levels of 4 types of TIICs (CD8+ T cells, DC, macrophages, and Th1 cells) were positively correlated with the high-MRPRS group (p < 0.05). The gene discussed is HLA-C; the disease is nonpapillary renal cell carcinoma.