Recently, m6A modifications have been shown to play a role in the regulation of immune cells, such as the following: METTL3-mediated m6A modification increased the translation of certain immune transcripts and physiologically promoted the activation of dendritic cells (DCs) and DC-based T-cell responses (10), and ALKBH5 regulated m6A modification in the 3’UTR region of PD-L1 mRNA and inhibited the expansion and cytotoxicity of T cells by sustaining tumor cell PD-L1 expression (11). Here, CD274 is linked to neoplasm.