Moreover, the expression of WTAP, YTHDC1, YTHDC2, HNRNPC, and HNRNPA2B1 was significantly different between the ICB-resistant-related GPX3+ epithelial cells and ICB-response-related VCAM1+ epithelial cells (Figure 1D), indicating that the differential expression level of m6A regulators in ccRCC tissue and cell clusters may be related to the efficacy of immunotherapy. This evidence concerns the gene VCAM1 and nonpapillary renal cell carcinoma.