CD16+CD56+, CD3+CD4+ cell counts and the CD4+/CD8+ T cell ratio were significantly lower in CVID and CVID plus group at both time points compared to HC (CD16+CD56+ [(*p=0.017 and *p=0.023 for CVID group, *p=0.026 and *p=0.032 for CVID plus group)]; CD3+CD4+ [**p=0.004 and **p=0.002 for CVID group, ***p=0.0004 and ***p=0.00008 for CVID plus group)]; CD4+/CD8+ ratio [(**p= 0.002 and **p=0.005 for CVID, **p=0.001 and **p=0.002 for CVID plus group)] respectively). This evidence concerns the gene CD8A and common variable immunodeficiency.