In this study, to further clarify the role of EGR2 in autoinflammation condition versus normal physiological condition, we derived conditional EGR2 knockout mice in both B6/lpr (a lymphoproliferative, systemic lupus erythematosus (SLE)-like autoimmune disease model) and normal B6 genetic background. This evidence concerns the gene EGR2 and systemic lupus erythematosus.