CD274 and immunodeficiency disease: First, because Vγ2Vδ2 T cells are species specific, we employed an immunodeficiency mouse model to investigate the efficacy of Vγ2 x PD-L1 plus Vγ2Vδ2 T cells, without examining whether this combination therapy could change or reshape the suppressive tumor microenvironment, or the in vivo toxicity of combo usage.