In fact, the activation, degranulation, and subsequent tumor cell killing mediated by Vγ2 x PD-L1 were all dependent on simultaneous binding to Vγ2Vδ2 T cell and PD-L1 expressing tumor cells, demonstrating the safety of our strategy in comparison to PD-L1 chimeric antigen receptor NK cells (36). This evidence concerns the gene CD274 and neoplasm.