In this paper, we have established that the glucocorticoids cortisol and dexamethasone can directly bind to the SARS-CoV-2 surface glycoprotein S1 and inhibit its interaction with ACE2, a major receptor used by SARS-CoV-2 (and other coronaviruses) for infection of the host (Figure 7). This evidence concerns the gene ACE2 and infection.