Type I Interferon response, RIG-I signaling, and multiple proteins known to be induced by interferon signaling including CXCL10 (also known as Interferon Gamma-induced protein, IP-10), MCP-1, MCP-2 and CXCL11 have been reported in a recent preprint to be associated with COVID-19 disease progression in a study of eight patients (22). Here, RIGI is linked to COVID-19.