LAIR1 and cancer: Overexpression of collagens by cancer cells is known to be associated with poor overall survival in several tumors such as lung (56, 57), colorectal (26, 58) and ovarian cancers (59, 60), and cancer cells are thought to exert LAIR-1-mediated immune evasion mechanisms through the remodeling of collagens in the tumor microenvironment (61) (Figure 2).