Since replication of the 30Kb CoV genome and the generation of sub-genomic RNAs have the potential to generate sufficient topological stress able to power the flip of right-handed A-RNA to left-handed Z-RNA (11), we were interested in the role played by the Z-RNA sensor protein ZBP1 (historically called Z-DNA Binding Protein 1) in CoVs infection. The gene discussed is ZBP1; the disease is infection.