ALOX5 and cystic fibrosis: This suggests that the reduced LXA4, LXB4, RvD2, RvD5, PD1 and RvE3 levels in CF samples were mainly due to a reduced 5-LO activity (either to produce 5-HETE from AA or to metabolize 12-HETE, 15-HETE, 17-HDOHE and 14-HDOHE) and/or an increased consumption of 5-HETE rather than a change in 12-LO or 15-LO activities.