In OSCC (7), non-small cell lung cancer (27, 28, 30), ovarian cancer (32), prostate cancer (38), and glioma (43), the expression levels of MIR4435-2HG and TGF-β1was positively correlated with each other, while no correlation between MIR4435-2HG and TGF-β1 was found in plasma of healthy persons. This evidence concerns the gene TGFB1 and Familial prostate cancer.