CARs are chimeric antigen-recognition receptors, consisting of an ectodomain, which binds a tumor specific cell surface receptor, and endodomains, consisting of CD3ζ as the signaling domain with co-stimulatory domains to provide robust activation (e.g. CD28, 4-1BB, or ICOS) (61). This evidence concerns the gene TNFRSF9 and neoplasm.