CD19 and neoplasm: CAR-modified γδ T-cells were first described by Rischer et al. (71), demonstrating specific in vitro tumor cell lysis using ZOL-expanded Vγ9Vδ2 T-cells with CD19- or GD2-directed CARs, followed by other studies confirming these findings using γδ T-cells containing CARs against a variety of targets (72–77).