CD4 and common variable immunodeficiency: We indicated reduced number of total, naϊve, memory B cells and plasmablasts, decrease in number of total, naϊve, central memory and regulatory CD4+ T cells and naϊve CD8+ T cells as well as an increase in CD21low and transitional B cells, effector memory and TEMRA CD4+ T-cell subsets as well as total, effector memory, TEMRA, activated and cytotoxic CD8+ T cells on genetically unsolved CVID patients (120).