We determined that two of the enzymes, i.e. ST6 β-Galactoside α-2,6-Sialyltransferase 1 (ST6GAL1) and Core 1 β,3-Galactosyltransferase 1 (C1GALT1) were upregulated by this treatment (Figure 4D); expression of both of those enzymes was increased in AD epidermis as detected before in AD skin. This evidence concerns the gene ST6GAL1 and Alzheimer disease.