Given the extended dysregulation of Helios expression to other pivotal T-cell subsets in lupus, such as CD4+ Tregs, Tconvs, DN, and γδ T cells, Helios expression may be a good candidate as a new and versatile marker for patients with SLE and perhaps for other autoimmune pathologies. Here, IKZF2 is linked to systemic lupus erythematosus.