Assessing these well-known lupus models from this new perspective, most of the data obtained indicates that diseased MPJ mice exhibit a less severe pathology than LPR mice, although both consistently present an altered DC compartment and aberrant Helios expression in CD4+ Tconv, CD4+ Treg, CD8+ Treg, and DN T cells as the disease develops. Here, CD8A is linked to systemic lupus erythematosus.