Indeed, other groups have reported lupus-like phenotypes after 5 months (as in MPJ) in mice with specific CD8+ Treg deficiencies (12, 14, 15), and, very recently, a significant reduction of Helios was described in total CD8+ T cells from patients with SLE (56) and in the equivalent human population to murine CD8+CD44+CD122+Ly49+ Tregs, called KIR+ CD8+ Tregs (9, 12). This evidence concerns the gene CD8A and systemic lupus erythematosus.