CD4 and systemic lupus erythematosus: Likewise, to search for new, useful molecular markers that may be suitable to be used in clinic practice, it will be necessary to explore Helios modulation not only in CD8+ Tregs but also in other well-known components of the immune system involved in the pathology of lupus, e.g., CD4+ Tregs, conventional CD4+ T cells (CD4+ Tconvs), double-negative T cells (DN T cells), and gamma delta (γδ) T cells.