However, studies have demonstrated that certain chemotherapeutic drugs, such as cisplatin and paclitaxel, effectively suppress tumor growth and metastasis by evoking the conversion from caspase 3-dependent apoptosis to pyroptosis (17, 81–83), which could explain why high activating levels of pyroptosis are associated with high TMZ sensitivity in glioma. Here, CASP3 is linked to central nervous system cancer.