However, studies have demonstrated that certain chemotherapeutic drugs, such as cisplatin and paclitaxel, effectively suppress tumor growth and metastasis by evoking the conversion from caspase 3-dependent apoptosis to pyroptosis (17, 81–83), which could explain why high activating levels of pyroptosis are associated with high TMZ sensitivity in glioma. The gene discussed is CASP3; the disease is neoplasm.