To determine the role of these host cells played in the control of metastasis following activated tumor-specific CD4+T cell transfer, we used Cd4–/– mice, Cd8–/– mice as recipient mice and found that CD4+ T-cell adoptive transfer also significantly reduced metastatic foci in the lung of these mice (Figures 1C, D and Supplementary Figure 3A). This evidence concerns the gene CD8A and neoplasm.