What’s more, CD4+ T cells have been proposed to have effector roles in the tumor microenvironment, including activation of local NK cells via secretion of effector cytokines, recruitment of CD8+ T cells by CXCL-10 release, and even HLA class II-dependent tumor cell killing (21); however, the precise mechanisms involved require further investigation. This evidence concerns the gene CXCL10 and neoplasm.