SPI1 and neoplasm: Despite most of the activated SMARTA cells exhibit an unskewed phonotype before transfer (Supplementary Figure 4), the majority of SMARTA cells from the draining lymph node (DLN) and lung were found to differentiate via the Th1 program, as evidenced by high expression of T-bet (Figure 2A), but not CXCR5, FOXP3, PU.1 or RORγt (Supplementary Figures 5A–D), indicating that Th1 cells are critical for tumor control.