A clinical cohort study showed that high expression of receptor for activated C kinase 1 (RACK1) inhibits macrophage recruitment and decreases the M1/M2 ratio (tumor having a higher M2 proportion) via the NF-KB pathway, promoting the development of OSCC, indicating RACK1 and the M1/M2 ratio are predictors of a poor prognosis in (253). The gene discussed is RACK1; the disease is neoplasm.