In the context of cancer, neutrophils release neutrophil elastase (NE) in large quantities that, through its influential protease activity, can cleave not only elastin but also other extracellular matrix proteins such as collagen, laminin, and numerous transmembrane proteins, which devastate the firm junctions between cells and provoke the exudation and migration of neutrophils (332, 333). The gene discussed is LAMB2; the disease is cancer.