GNLY and neoplasm: A favorable prognosis is associated with a number of differing immune factors such as: high levels of memory CD8+ T cells, high expression of Th1 cytokines, i.e., interferon gamma (IFN-γ) and IL-1, the development of a tertiary lymphoid structure (TLS) associated with the tumor, increased levels of cytotoxic mediators (granzymes, granulysin), low neutrophil–lymphocyte Ratio (NLR) and low to moderate vascularization of the tumor (75).