Results demonstrated that the occurrence of ILD was significantly correlated with sex (3.527 [1.325–9.632], p = 0.012), current smoker (3.168 [1.217–8.243], p = 0.018), and circulating concentrations of RF (1.002 [1.000–1.004], p = 0.017), CRP (1.009 [1.002–1.016], p = 0.012), and MMP-3 (2.976 [1.142–7.710], p = 0.026). This evidence concerns the gene MMP3 and interstitial lung disease.