CRP and aortic valve insufficiency: In the derivation cohort, results of the univariable logistic regression analysis showed ESR (continuous variable; P < 0.001), high ESR (categorical variable, yes or no; P < 0.001), CRP (continuous variable; P = 0.020), high CRP (categorical variable, yes or no; P = 0.005), NIH criterion 1 (P = 0.020), NIH criterion 3 (P = 0.014), NIH criterion 4 (P < 0.001), malaise or weight loss (P = 0.043), carotidynia (P = 0.014), and aortic incompetence (P = 0.023) as variables significantly associated with active disease (Table 2).