However, worldwide data initially reported the phenomenon that cystic fibrosis (CF) patients had a relatively improved Covid-19 survival, even though the defect in cystic fibrosis transmembrane conductance regulator protein (CFTR), impairing chloride and bicarbonate secretion, causes impaired mucociliary clearance and an exaggerated proinflammatory response that could be driven by infection (139). This evidence concerns the gene CFTR and cystic fibrosis.