Moreover, as DDX17 facilitated HBV transcription and replication in a ZWINT-dependent manner, we co-transfected the shRNAs targeting DDX17 (shDDX17) and ZWINT overexpression plasmid with Flag-HBx into Huh-7 cells to assess the involvement of ZWINT in DDX17-mediated HBV in relation to HCC migration. This evidence concerns the gene DDX17 and hepatocellular carcinoma.