In addition, HBx was shown to induce the expression of the miRNA TLRC-m0008_3p (miR-3928v) through the NF-kB/EGR1 signaling pathway, resulting in the downregulation of the tumor suppressor gene VDAC3 to accelerate the progression of HCC (38). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.