PDK1 and diabetic kidney disease: Treatment of podocytes with LPS decreased the expression of 3-phosphoinositide-dependent kinase-1 (PDK1), stimulated the pro-apoptotic p38MAPK pathway, and induced apoptosis, which contributed to the occurrence of DKD, while the immunomodulator 4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid (GIT27), which inhibits the TLR signal pathway, can prevent this pathological change (68).