Fan et al. screened out 8 independent prognostic clinicopathological factors (age, sex, preoperative CEA, perineural invasion, tumor deposits, tumor grade, T stage, and N stage) for non-metastatic rectal cancer, and constructed a prognostic prediction nomogram with the concordance index (C-index) of 0.71 (6). This evidence concerns the gene CEACAM5 and rectal cancer.