Several sodium channel-related pathogenic genes have been identified in ventricular arrhythmias without structural heart disease, including SCN5A, SCN1B, SCN2B, SCN3B, SCN4B, GPD1L, RANGRF, SCN10A, among which SCN5A is the most reported (Table 2). This evidence concerns the gene SCN5A and Ventricular arrhythmia.