Studies have shown that ATO induces a decrease in the transcription level of long non-coding RNA KCNQ1OT1 in the KCNQ1 locus, while KCNQ1OT1 silencing can inhibit the expression of KCNQ1, thus prolonging action potential duration in vitro and causing LQTS in vivo (176). This evidence concerns the gene KCNQ1 and familial long QT syndrome.