KCNQ1OT1 and familial long QT syndrome: Studies have shown that ATO induces a decrease in the transcription level of long non-coding RNA KCNQ1OT1 in the KCNQ1 locus, while KCNQ1OT1 silencing can inhibit the expression of KCNQ1, thus prolonging action potential duration in vitro and causing LQTS in vivo (176).