KCNIP2 and heart disorder: KCHIP2 is heterogeneously expressed in the human and mouse ventricular walls, and although there have been no cases of association of KCHIP2 mutations with cardiac disease, functional studies have shown that the gene defect alters repolarization gradients, eliminates fast Ito, and increases the susceptibility of murine ventricular cells to ventricular tachycardia (30).