At present, most genes related to idiopathic ventricular fibrillation overlap with the pathogenic genes of hereditary ventricular arrhythmias, such as CALM1~3, RYR2, TRDN, CACNA1C, SCN5A, KCNE5 (50, 125, 132–137). This evidence concerns the gene RYR2 and paroxysmal familial ventricular fibrillation.