As a result, further studies have associated dysregulation of EZH2 with various diseases, including CVD (cardiac hypertrophy, fibrosis, atherosclerosis, ischemic heart disease, myocardial regeneration, cardiomyopathy, pulmonary arterial hypertension, atrial fibrillation) (26, 32–37), various solid cancers (lung, breast, endometrial, ovarian, nasopharyngeal, thyroid, liver, prostate, and glioblastoma) (8, 17, 38–40), as well as hematopoietic cancers (Non-Hodgkin's, large B-cell, and follicular lymphoma) (41, 42). Here, EZH2 is linked to pulmonary arterial hypertension.