FGF23 and chronic kidney disease: Although the pathogenesis of CKD is complex, evidences show that exogenous glycerol-3-phosphate (G-3-P) stimulated bone and bone marrow fibroblast growth factor-23 (FGF-23) production through local G-3-P acyltransferase mediated (GPAT-mediated) LPA synthesis (11, 32).