Zhou et al. proved that SNPs in the 3′UTR of amyloid precursor protein (APP) alter the regulation of APP expression by miRNAs, including miR-144-3p, miR-101-3p, miR-383-5p, and miR-153-3p, and subsequently modulate the occurrence of Alzheimer's disease (60). The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.