The mRNA levels of PDE4A (cAMP-specific, LFC −1.18, padj = 3.011E-12), PDE4D (cAMP-specific, LFC −0.68, padj = 0.02), and PDE1C (cAMP/cGMP dual specificity, LFC−0.55, padj = 0.006) decreased significantly, whereas those of PDE3B (cAMP/cGMP dual specificity, LFC 0.78, padj = 0.003) and PDE7A (cAMP-specific, LFC 0.72, padj = 8.6E-04) increased significantly in the IHD group. Here, PDE4D is linked to myocardial ischemia.