The results were consistent with the RNA-seq data showing that mRNA levels of NPPA (padj = 0.036), NPPB (padj = 0.046), and MME (padj = 0.006) increased significantly under IHD condition, whereas that of NPPC (padj = 0.001) decreased remarkably when compared with controls (Figure 4B). The gene discussed is NPPA; the disease is myocardial ischemia.