Wen et al. also showed I.V. administration of Umbilical Cord MSCs (UC-MSCs) was effective in attenuating aneurysmal expansion, reducing elastin degradation and fragmentation, inhibiting MMPs and TNFα expression, and to promote contractile phenotype of SMCs in the AAA wall of elastase-induced rat model (100). The gene discussed is ELN; the disease is triple-A syndrome.