Moreover, patients with LN and MCD exhibited significantly weaker expression of ANXA1 in glomeruli and tubulointerstitium than AAV patients (0.031 ± 0.028 vs. 0.178 ± 0.056, P < 0.001; 0.049 ± 0.021 vs. 0.178 ± 0.056, P < 0.001; 0.002 (IQR 0.001–0.008) vs. 0.111 (IQR 0.081–0.137), P < 0.001; 0.002 (IQR 0.001–0.007) vs. 0.111 (IQR 0.081–0.137), P < 0.001, respectively) (Figures 4A,B). Here, ANXA1 is linked to lobular neoplasia.