RPAIN and age-related macular degeneration: We found 25 genes shared between clocks developed with dermal fibroblast and clocks developed with combined retina-dermal fibroblast datasets, viz., MLLT11, FBN2, ALKBH3, FAS, BST2, XPNPEP1, GPC2, ZNF518B, TEAD2, SYNE2, DUSP2, CPNE8, GDF11, C16orf72, CKAP4, TEAD4, PEG10, BCAS4, APBB1IP, SEMA4C, RIN2, LNX1, RNF149, EXOC8, RPAIN, and 2 genes shared between retina MGS1 and joint retina-dermal clocks, viz., LAMA4 and MYO1D. Interestingly, literature evidence has implicated some of these genes in AMD (viz., C16orf72, GDF11, FBN2) (58–61).