A phase II, open-label study of efgartigimod in patients with pemphigus vulgaris and pemphigus foliaceus showed that efgartigimod induced early decrease of anti-desmoglein 1 and 3 autoantibodies in serum, representing a well-tolerated option of achieving early disease control and complete clinical remission of pemphigus while early corticosteroid tapering (83). Here, DSG1 is linked to pemphigus.