In order to eliminate the antigen-specific B cells that produce antibodies, Ellebreht et al. created a chimeric autoantibody receptor (CAAR), with the autoantigen Dsg3 as the CAAR extracellular domain, to engineer T cells to deplete the autoimmune memory B cells directly and Dsg3-specific short-lived plasma cells indirectly in PV patients (84). The gene discussed is DSG3; the disease is acquired polycythemia vera.