The study by Cardinale et al. included 2,179 patients solely undergoing lung cancer surgery, a 10% incidence of AKI was reported, and, among the independent predictors of AKI, serum Scr [area under the curve (AUC) 0.70 (95% CI 0.67–0.74)] and NT-proBNP [AUC 0.71 (95% CI 0.67–0.74)] provided the highest predictive accuracy, and their combination further significantly improved AKI prediction [AUC 0.74 (95% CI 0.71–0.77)] (25). This evidence concerns the gene NPPB and acute kidney injury.