APOE and cerebral amyloid angiopathy: For example, occipital amyloid burden has been linked to cerebral amyloid angiopathy (CAA), a form of SVD which predominantly occurs in posterior areas of the brain and is the direct result of Aβ deposition in the vessel walls.59 In addition, the presence of (posterior) CAA has been associated with higher prevalence of APOE-ε4 carriership and posterior and specifically occipital WMH burden,60 providing further support for a vascular-independent pathway of WMH pathology.