They are prevalent in cognitively unimpaired older individuals and associated with vascular risk factors.2,3 Amyloid-β pathology (Aβ) is hypothesized to initiate the Alzheimer’s disease pathological cascade,4,5 followed by the aggregation of intraneuronal hyperphosphorylated tau (p-tau), and eventual grey matter volume loss.6,7 Both WMH and amyloid burden can be observed years before the onset of cognitive symptoms and have been shown to contribute to cognitive impairment.8,9. Here, MAPT is linked to Alzheimer disease.