MAPT and early-onset autosomal dominant Alzheimer disease: They are prevalent in cognitively unimpaired older individuals and associated with vascular risk factors.2,3 Amyloid-β pathology (Aβ) is hypothesized to initiate the Alzheimer’s disease pathological cascade,4,5 followed by the aggregation of intraneuronal hyperphosphorylated tau (p-tau), and eventual grey matter volume loss.6,7 Both WMH and amyloid burden can be observed years before the onset of cognitive symptoms and have been shown to contribute to cognitive impairment.8,9