VCAM1 and rheumatoid arthritis: The activation of RA synovial fibroblasts (RASFs) by inflammatory factors subsequently activates and increases the expression of cell adhesion molecules (CAMs), including, integrins and vascular cell adhesion molecule 1 (VCAM-1), which mediate adhesion to the extracellular matrix (ECM) in the inflamed RA synovium and facilitate joint damage (5).