However, JXD therapy suppressed BLM-induced upregulation of TGF-β, α-SMA, collagen I, fibronectin, and promoted BLM-induced downregulation of E-cadherin, which indicated that JXD may reduce BLM-induced PF via inhibiting TGF-β1 pathway. This evidence concerns the gene TGFB1 and pemphigus foliaceus.