In order to further clarify the possible molecular mechanism of JXD attenuating BLM-induced PF, the protein expression of α-SMA, TGF-β1, collagen I, fibronectin, E-cadherin, p-Smad2, Smad2, p-Smad, and Smad3 were measured. The gene discussed is SMAD2; the disease is pemphigus foliaceus.