AKT1 and premature menopause: Huang Changsheng believed that quercetin might be one of the main effective ingredients in Cuscuta flavonoids for the treatment of POF, and in a rat model of POF, both Cuscuta flavonoids and quercetin alone could inhibit the process of POF through activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway [27, 28].