In addition, whole cell supplementation of B. bifidum LMG13195 to systemic lupus erythematosus (SLE) patients prevented CD4+ lymphocyte over-activation and reduced Interleukin (IL)-6 and Interferon (IFN)-γ in the serum suggesting an anti-inflammation activity (López et al., 2016). The gene discussed is CD4; the disease is systemic lupus erythematosus.