In lower grade glioma (LGG) (grade II and III), the expression of MCM3AP-AS1 was significantly higher than that of glioblastoma multiforme (GBM), and its expression was significantly downregulated with increasing glioma tumor grade, suggesting that MCM3AP-AS1 may be a protective factor in glioma.[24, 25]. Here, MCM3AP is linked to central nervous system cancer.