DPP4 and neoplasm: In both in vivo and in vitro experiments, downregulation of MCM3AP-AS1 was found to inhibit tumorigenicity, tumor-associated inflammation and angiogenesis in ccRCC, and MCM3AP-AS1 upregulated the DPP4 gene by entrapment E2F1 into the DPP4 gene promoter to achieve regulation of pro-angiogenesis and pro-inflammation in ccRCC [44].