In the recent paper, the whole-exome sequencing (WES) was performed in 52/281 pediatric SLE cases who fulfilled one of the following criteria: early onset of the disease (<5 years), family history of autoimmune disease and complicated conditions, and causative mutations in 5 genes (SLC7A7, NRAS, TNFAIP3, PIK3CD, and IDS) were identified in 12 patients (23.1%) (13). Here, IDS is linked to autoimmune disease.