In pancreatic cancer, CMTM4, LAMB3, and IGF2BP2 all promote tumor proliferation, invasion, and metastasis through this activation pathway while inhibiting the cell cycle and apoptosis to play a carcinogenic role (Xu et al., 2019; Zhang et al., 2019; Li et al., 2020). The gene discussed is CMTM4; the disease is neoplasm.