RIPK3 and neoplasm: Koo et al. (2015) reported RIPK3 was decreased or even absent in some cancer cell lines. This downregulation was proven to be correlated with tumor progression and a worse prognosis (Feng et al., 2015; Koo et al., 2015; Bozec et al., 2016). Zhao et al. (2021) summarized necroptosis-related lncRNAs and established a novel model for prognostic prediction in gastric cancer.