Zupan et al. (2018) reported that the high expression of VEGFA indicating cartilage or bone degeneration is associated with pre-osteoarthritis. Furthermore, overexpression of miR-140-5p alleviates knee osteoarthritis by downregulating VEGFA in a rat model (Liu et al., 2022). BTG2 was found to be a critical gene related to inflammation in OA. Recent evidence showed that BTG2 is a hub node in the ingenuity pathway network of facet joint OA, which proposed its function in mediating signaling pathways by affecting other genes (Chen et al., 2020). This evidence concerns the gene BTG2 and osteoarthritis, knee.