On the contrary, the KDM6B expression level increased in the tumor tissues of CHOL (cholangiocarcinoma), HNSC (head and neck squamous cell carcinoma) (both p < 0.001), ESCA (esophageal carcinoma) and KIRC (kidney renal clear cell carcinoma) (both p < 0.05). The gene discussed is KDM6B; the disease is head and neck squamous cell carcinoma.