MRC1 and cancer: Table 2 shows the correlation between the KDM6B expression level, TMB, and MSI in various cancers, in which the KDM6B expression level was significantly different with its matched normal tissues. As for the MMR genes, KDM6B was positively correlated with all five MMR genes in GBM, HNSC-HPV-, KIRC, KIRP, LIHC, PRAD, SARC, and THCA, whereas COAD was the sole type that only had a negative correlation with KDM6B (Figure 6C).