BECN1 and colorectal carcinoma: Finally, we selected autophagy pathway-related proteins Beclin-1 and p62 for gene function verification of ATP2A1. It demonstrated that the expression of Beclin-1 remarkably increased with the down-regulation of ATP2A1, and the protein level of p62 was positively related to that of ATP2A1. As reported, Beclin-1 and p62 are two promising prognostic markers for CRC (Schmitz et al., 2016).