Several structural variations are typical of BRCA1/2-deficient cancer genomes, including deletions up to 100 kb, unclustered tandem duplications of ∼10 kb associated with BRCA1 mutations (Willis et al., 2017), and deletions up to 1-10 kb in cancers are found in patients with BRCA2 mutations (Degasperi et al., 2020). The gene discussed is BRCA2; the disease is cancer.